Colloquium: Andreas Möglich

04/02/2019

16:00

Vrije Universiteit, WN-Q112, De Boelelaan 1081, 1081 HV Amsterdam

Colloquium: Controlling Nucleic Acids by Light

Prof. Dr. Andreas Möglich - Department of Biochemistry, Faculty of Biology, Chemistry & Earth Science, University of Bayreuth, Germany

LaserLaB

Sciences

Lecture

Sensory photoreceptors underpin diverse adaptations of organismal behavior, lifestyle and physiology to incident light. In optogenetics, photoreceptors double as genetically encoded, light-gated actuators and enable the noninvasive control of cellular circuits with spatiotemporal precision. Against this backdrop, we investigate and engineer blue-light-responsive receptors of the light-oxygen-voltage (LOV) family that mediate optogenetic control of various nucleic-acid-based processes, e.g., transcription, translation and endonuclease activity. Biochemical analyses of receptor structure, function and signaling mechanism unravel the molecular bases for light-dependent allostery and inform additional protein engineering efforts.