Laser Based Microscopy

Program manager: Prof.dr. Marloes Groot

Within this program we develop nonlinear and coherent microscopic tools for studies on cellulair and tissue scale in the field of neurobiomedical research.The ability to look at living organisms with microscopic resolution has been of tremendous importance for understanding biological structure and function. Here, we develop nonlinear optical techniques to obtain images in deep-tissue with sub-cellular resolution, with and without external contrast agents (dyes, GFP). Label-free in-vivo images are obtained through third harmonic generation. Current research lines are the development of multipulse microscopies to obtain sub-diffraction resolution and the application of THG and digital holography in neuromedical research. This research is closely integrated with the Neuroscience Campus Amsterdam.